What is tirzepatide?
Tirzepatide (internal code LY3298176) is a synthetic 39-amino-acid peptide developed by Eli Lilly, engineered to co-activate two incretin receptors: GLP-1 and GIP. This dual action was a pharmacological first when it launched clinical trials in 2018 — until then, every approved weight-loss drug hit a single receptor (GLP-1). FDA approved it as Mounjaro (type 2 diabetes, May 2022) and Zepbound (obesity, November 2023), instantly making it the strongest incretin medicine on the global market.
In research-use-only (RUO) settings, tirzepatide is the new benchmark against which every competitor — retatrutide, cagrisema, orforglipron, survodutide — is being measured. It is studied for body weight regulation, glycemic control, hepatic steatosis, and cardiovascular markers. Storage is stable lyophilized at 2–8°C; reconstituted in bacteriostatic water, solution stability reaches 28 days at 2–8°C. Lab Peptides France ships every vial with a certified COA (HPLC ≥98%) and traceable batch number.
Dual agonist mechanism: GLP-1 / GIP
GLP-1
Slows gastric emptying, enhances glucose-dependent insulin secretion, suppresses appetite via hypothalamic POMC/AgRP neurons. The foundational lever of every incretin drug.
GIP
Amplifies post-prandial insulin response, modulates adipose tissue lipolysis, improves glucose disposal in insulin-resistant tissues. The ingredient that separates tirzepatide from semaglutide.
GIP was long considered a failed therapeutic target — until Eli Lilly showed that pairing it with GLP-1 unlocks synergistic weight loss. The twincretin concept is now the foundation of the next generation (retatrutide adds glucagon on top of this dual base).
Clinical studies SURMOUNT / SURPASS
Jastreboff et al. — NEJM 2022 (SURMOUNT-1)
Phase 3 · n=2539Pivotal obesity trial, 72 weeks of weekly tirzepatide dose-escalation (5, 10, 15mg) vs placebo. Primary endpoint: percent body weight change.
- -22.5% body weight @ 15mg / 72 weeks
- -19.5% body weight @ 10mg / 72 weeks
- 96% of subjects lost ≥5% weight
Frías et al. — NEJM 2021 (SURPASS-2)
Phase 3 · T2D · n=1879Head-to-head trial: tirzepatide vs semaglutide 1mg in type 2 diabetes over 40 weeks. The study that established tirzepatide as the new glycemic standard.
- -2.30% HbA1c @ 15mg tirzepatide
- -1.86% HbA1c @ semaglutide 1mg (comparator)
- -11.2kg body weight @ 15mg (vs -5.7kg semaglutide)
SURMOUNT-3, 4, 5 and cardiovascular readouts — Wadden et al. 2023 showed -26.6% body weight when tirzepatide was added after intensive lifestyle intervention. SURMOUNT-MMO (ongoing) will read out hard cardiovascular endpoints in 2027, expected to cement tirzepatide as standard of care in high-risk obesity.
Choose your tirzepatide dose
Four formats cover every research protocol — from standard weekly dosing (10mg, 15mg) to extended multi-subject research (30mg, 60mg). Each vial is HPLC ≥98%, COA-certified, shipped from France with discrete cold-chain packaging.
Why Lab Peptides France
HPLC ≥98% purity, every batch
Third-party HPLC-MS certification. COA downloadable on every product page, batch number traceable. No gray-market powder.
Stocked in France
Cold-chain packaging, discrete neutral boxes, stocked in France (no customs). Dispatches leave Tuesday and Friday, then 2 to 3 business days with Colissimo. Tracking included.
French-speaking support
Team based in Europe, replies under 4h on weekdays. Technical questions, reconstitution guidance, order tracking.
5% automatic cashback
Every paid order credits 5% of its subtotal to your loyalty balance, convertible into a promo code from 5 €. Card, Apple Pay and Google Pay accepted.
Ready to order?
Most popular research format: tirzepatide 15mg (SURMOUNT-1 top dose). One vial covers a standard 5-6 week escalation protocol at 2.5mg weekly.
Order Tirzepatide 15mgFrequently asked questions
Is tirzepatide legal in France?
Yes, as a research compound (RUO) intended exclusively for laboratory use. The Eli Lilly Mounjaro/Zepbound molecule is approved as a prescription medicine; in RUO, sale and possession for research are legal, but any human, veterinary, or therapeutic use is strictly prohibited outside the medical channel.
How does it differ from semaglutide?
Semaglutide activates one receptor (GLP-1), tirzepatide activates two (GLP-1 + GIP). The SURPASS-2 trial (Frías NEJM 2021) showed that weekly tirzepatide 15mg outperformed weekly semaglutide 1mg across every metabolic endpoint: −2.30% vs −1.86% HbA1c, −11.2kg vs −5.7kg body weight. It is currently the strongest approved incretin.
How does it differ from retatrutide?
Retatrutide adds a third receptor (glucagon/GCGR) on top of tirzepatide's GLP-1 + GIP base. Phase 2 data (Jastreboff NEJM 2023) show −24.2% body weight with retatrutide 12mg at 48 weeks, ~7 points more than tirzepatide 15mg at 72 weeks. Tirzepatide remains the approved standard today; retatrutide is likely its successor after TRIUMPH Phase 3 (2026-2027).
How to reconstitute tirzepatide?
Use sterile bacteriostatic water, typical ratio 3ml per 15mg (final concentration 5mg/ml). Slowly inject water against the vial wall, do not shake, let it sit 2 minutes then gently roll. Stable 28 days at 2–8°C after reconstitution. Full detailed guide on /en/reconstitution-guide.
Which dose for a first cycle?
For a standard escalation protocol (2.5mg → 5mg → 7.5mg → 10mg → 12.5mg → 15mg, one step per month), the 15mg format typically covers the first 2-3 months. For a quick efficacy exploration, 10mg is enough. 30mg and 60mg formats are reserved for multi-subject or extended-duration protocols.
Do you ship to France? How fast?
Yes. Dispatches leave Tuesday and Friday, then allow 2 to 3 business days with Colissimo. Stocked in France, no customs. Discrete packaging, cold chain preserved, tracking included. Permanent stock on all 4 doses.
Which payment methods do you accept?
Card (Visa, Mastercard, CB), Apple Pay and Google Pay. Every paid order credits 5% of its subtotal to your loyalty balance, convertible into a promo code from 5 €.
Will I receive a Certificate of Analysis (COA)?
Every batch ships with a third-party COA (HPLC-MS, ≥98% purity), downloadable directly from the product page before purchase. Batch number is traceable.