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11 in stockships Wednesday, November 4

Certificate of analysis
In stock in France
Ordered with its water: shipped in a magnetic box

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The vial alone cannot be used as is. Add what you need to prepare it:

10mg vialIncluded

Eau Bactériostatique

7,90 €

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Research Use Only (RUO) · Prohibited for human or veterinary use.

Key facts

PT-141 is a synthetic peptide supplied lyophilised, intended exclusively for laboratory scientific research. Technical sheet, storage and analyses below.

Protocol and preparation

Reconstitution for this format (10 mg)Standard volumes used in laboratory settings

Water added	Concentration	Reading marker
1 ml	10 mg/ml	10 UI = 1 mg
2 ml	5 mg/ml	40 UI = 2 mg

The volume of water does not change the product, only its concentration. Add the water slowly along the vial wall, then swirl without shaking.

Asepsis
Disinfect surfaces and stoppers (70% alcohol).
Solvent
Draw the required volume of bacteriostatic water.
Introduction
Add gently against the vial wall (avoid a direct jet on the powder).
Solubilization
Roll the vial gently. Do not shake vigorously (degradation risk).

Solution storage Once reconstituted: 2-8°C (refrigerator).

Warning Theoretical tool for chemical handling. Does not constitute medical advice.

I open the dilution calculator

What is normal on arrivalThe observations that worry customers, and are not defects

The amount of powder looks tiny. A lyophilisate takes up a few millimetres at the bottom of the vial, sometimes just a translucent film. The stated weight is there.
The powder is compact, stuck to the wall or to the stopper. Transport moves the freeze-dried cake around. It changes nothing to reconstitution.
The vial carries no individual label. That is our standard packaging, not a downgraded vial.
After reconstitution, deposits or filaments appear. This is common, especially with small molecules. Let it settle and roll the vial between your palms, never shake it.
The parcel is plain. Nothing on the outside indicates the contents or the brand name.

What is not normal: a cracked vial, an uncrimped cap or a stopper that moves, powder that has liquefied or changed colour. In those specific cases, write to us with a photo and we take the vial back.

Documented synergies

With PDE5 (sildenafil, tadalafil): complementary mechanisms, PT-141 acts on desire, PDE5 on vasodilation. Combinations are empirically described but few formal studies. Monitor blood pressure.
With oxytocin (intranasal): both activate oxytocin but through different pathways, theoretical addition.

This product is not intended for human use. The protocols described are examples drawn from scientific literature and documented off-label practices, provided strictly for informational purposes for research work on non-human models.

Technical data

Reconstitution: 2 ml d'eau → 5 mg/ml. 10 UI = 0,5 mg ; 20 UI = 1 mg.
Peptide sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
Molecular formula: C50H68N14O10
Molecular weight: 1025.2 g/mol
CAS number: 189691-06-3
Physical form: Poudre lyophilisée
Recommended solubility: Eau bactériostatique, NaCl 0,9%
Storage conditions: Au réfrigérateur (+2 à +8 °C), à l'abri de la lumière. En poudre, possible au congélateur pour une conservation longue. Une fois préparé : réfrigérateur, jamais au congélateur.
Use: Research reagent, in vitro only (RUO)

Storage & handling

Sealed unreconstituted vialIn the fridge (+2 to +8 °C); for long-term storage (over 3 months), a -20 °C freezer is an option, stability 24 months. At 2-8 C, stability 12 months. At room temperature (20-25 C), maximum 30 days stability; beyond, hydrolysis of peptide bonds and oxidation of N-terminal methionine (Nle in PT-141 is the methionine replacement precisely to reduce this risk).

After reconstitution in bacteriostatic water

4-8 C (refrigerator): optimal stability 14 days, acceptable up to 21 days with strict hygienic handling.
-20 C: acceptable for aliquots. One freeze-thaw cycle tolerated; avoid multiple cycles.
Light: keep protected.
pH: solution stable pH 4.5-6.5.

Visual signs of degradation

Cloudy veil or precipitate: peptide aggregation, structural degradation.
Deep yellow coloration: Trp or His oxidation, reduced activity.
Abnormal odour: advanced degradation.

Laboratory documentationReconstitution date, COA lot, storage conditions, to be recorded for traceability.

Mechanism of action

The PT-141 mechanism is central and articulates primarily around melanocortin receptors. Five subtypes MC1R-MC5R exist in humans: MC1R (skin/hair pigmentation), MC2R (adrenal cortex, cortisol), MC3R and MC4R (central nervous system, food intake, sexual function), MC5R (exocrine glands). PT-141 is a preferential MC3R/MC4R agonist with reduced affinity for MC1R (key difference with Melanotan II, which minimises pigmentation).

MC4R activation in the paraventricular nucleus of the hypothalamus triggers a neuroendocrine cascade: oxytocin release from magnocellular neurons, dopamine increase in the ventral tegmental area and nucleus accumbens (reward circuits), spinal parasympathetic activation (sacral parasympathetic nucleus). These three effects converge towards facilitation of sexual arousal: oxytocin modulates motivation and attachment, dopamine creates anticipatory desire, and parasympathetic activation potentiates the peripheral vascular response (tumescence).

Studies and references

PT-141 and bremelanotide literature covers more than 100 publications over 20 years.

Neurobiology and animal modelsPfaus 2011 Obstet Gynecol Clin North Am summarised PT-141 neurobiology in rat and primate models: activation of hypothalamic oxytocin, lordosis in female rats in receptive behaviour, restoration of sexual behaviour after castration. Andersson 2011 Eur Urol characterised nerve pathways by c-Fos brain imaging.

Off-label and community male usePT-141 is used off-label in men for ED non-responder to PDE5 and in longevity/performance research communities. Observational data are abundant but non-randomised.

Critical limitationThe RECONNECT trial was criticised for the modesty of the clinical effect (increase of 0.5-0.7 point FSFI on a 1-5 scale), the high dropout proportion (23 %), and the large placebo effect (20-25 % placebo responders). PT-141 remains a useful tool but not a magic solution. In men, the absence of a dedicated phase 3 trial limits generalisations.

1
Excitation sexuelleAn effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141)
Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, Harning R · Journal of Sexual Medicine · 2006

The listed studies are provided for documentation and research purposes only. They do not constitute a therapeutic indication nor a recommendation for human use. This product is strictly for laboratory use only (RUO).

Frequently asked questions

What is the purity of PT-141?

PT-141 meets an HPLC specification of ≥ 98%, and its certificate of analysis is published on this page: check it before you order.

How should PT-141 be stored?

Before reconstitution, lyophilized PT-141 is stable for several weeks at room temperature, and for several months in the fridge or freezer. Shipping does not degrade it. Once reconstituted, keep the solution between +2°C and +8°C, away from light, and do not freeze it.

How do I reconstitute PT-141 10mg?

To reconstitute PT-141, use bacteriostatic water or sterile 0.9% NaCl. Add the solvent gently along the wall of the vial, then roll it slowly (do not shake). Details are in our reconstitution guide.

Is a certificate of analysis (COA) available?

Yes: the certificate of analysis for PT-141 is published on this page and can be checked before you order. It shows the results measured by the laboratory.

Is PT-141 intended for human consumption?

No. PT-141 is intended exclusively for in vitro and in vivo scientific research (Research Use Only - RUO). It is not approved for human or veterinary use. Its purchase is reserved for laboratories, researchers and scientific institutions.

What are the research applications of PT-141?

PT-141 is part of our Melanocortins range. It is used in scientific research for in vitro and in vivo studies. Specific applications depend on the research protocol. See the scientific literature (PubMed) for publications on this peptide.