Semaglutide 10mg - 49 € | Metabolism

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49,00 €

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1 vial = 4.2 to 5.9 weeks at 1.7-2.4 mg per week

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Ordered with its water: shipped in a magnetic box

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Eau Bactériostatique

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Research Use Only (RUO) · Prohibited for human or veterinary use.

Key facts

Semaglutide is a synthetic peptide supplied lyophilised, intended exclusively for laboratory scientific research. Technical sheet, storage and analyses below.

Protocol and preparation

Reconstitution for this format (10 mg)Standard volumes used in laboratory settings

Water added	Concentration	Reading marker
1 ml	10 mg/ml	10 UI = 1 mg
2 ml	5 mg/ml	40 UI = 2 mg

The volume of water does not change the product, only its concentration. Add the water slowly along the vial wall, then swirl without shaking.

Asepsis
Disinfect surfaces and stoppers (70% alcohol).
Solvent
Draw the required volume of bacteriostatic water.
Introduction
Add gently against the vial wall (avoid a direct jet on the powder).
Solubilization
Roll the vial gently. Do not shake vigorously (degradation risk).

Solution storage Once reconstituted: 2-8°C (refrigerator).

Warning Theoretical tool for chemical handling. Does not constitute medical advice.

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What is normal on arrivalThe observations that worry customers, and are not defects

The amount of powder looks tiny. A lyophilisate takes up a few millimetres at the bottom of the vial, sometimes just a translucent film. The stated weight is there.
The powder is compact, stuck to the wall or to the stopper. Transport moves the freeze-dried cake around. It changes nothing to reconstitution.
The vial carries no individual label. That is our standard packaging, not a downgraded vial.
After reconstitution, deposits or filaments appear. This is common, especially with small molecules. Let it settle and roll the vial between your palms, never shake it.
The parcel is plain. Nothing on the outside indicates the contents or the brand name.

What is not normal: a cracked vial, an uncrimped cap or a stopper that moves, powder that has liquefied or changed colour. In those specific cases, write to us with a photo and we take the vial back.

Semaglutide 10mg reconstitution: recommended volume 2ml bacteriostatic water 0.9% benzyl alcohol, giving final concentration 5 mg/ml.

Consumption on this scheme: 0.25 + 0.25 + 0.25 + 0.25 + 0.5 + 0.5 + 0.5 + 0.5 + 1 + 1 + 1 + 1 + 1.7 + 1.7 + 1.7 + 1.7 + 2.4 = 15.7 mg cumulative over 17 weeks. A 10mg vial covers about 65% of this complete cycle. For an integral STEP cycle, plan 2 10mg vials or one 20mg + one 5mg backup.

Technical data

Reconstitution: 2 ml d'eau → 5 mg/ml. 5 UI = 0,25 mg ; 10 UI = 0,5 mg.
Peptide sequence: HXEGTFTSDVSSYLEGQAAKEFIAWLVRGRG (X = Aib ; lysine acylée)
Molecular formula: C187H291N45O59
Molecular weight: 4113.58 g/mol
CAS number: 910463-68-2
Physical form: Poudre lyophilisée
Recommended solubility: Eau bactériostatique, NaCl 0,9%
Storage conditions: Au réfrigérateur (+2 à +8 °C), à l'abri de la lumière. En poudre, possible au congélateur pour une conservation longue. Une fois préparé : réfrigérateur, jamais au congélateur.
Use: Research reagent, in vitro only (RUO)

Storage & handling

Lyophilised semaglutide stores for 24 months in sealed vial at room temperature (15-25°C) protected from direct light. No pre-reconstitution refrigeration required. After reconstitution in bacteriostatic water, the solution peptide stores for 21-28 days at 2-8°C, beyond progressive chemical degradation by peptide hydrolysis measurable by HPLC. Fragile chemical structure: despite stabilisation modifications (Aib8, Arg34, C18 diacid), semaglutide remains a long peptide (30 amino acids) with sensitivity sites:

N-terminal amide bond: sensitive to acid or enzymatic hydrolysis. - Methionine residue Met14: oxidation to methionine sulphoxide under prolonged dissolved oxygen exposure. - Glutamic linker ester bond: possible hydrolysis in acidic solution (pH < 5). - C18 acylated chain: chemically stable but can undergo progressive beta-oxidation over several weeks. Optimal storage conditions:
Unopened vial: 15-25°C, original cardboard packaging, protected from light, humidity < 60%. - Opened reconstituted vial: strict 2-8°C, vertical position, vial covered or in cardboard box for light protection, do not freeze. Temperatures > 30°C accelerate peptide degradation in solution. Errors to avoid:
Freeze-thaw: freeze-thaw cycles form ice crystals denaturing peptide tertiary conformation, 20-40% activity loss per cycle. - Direct solar exposure: Met14 methionine and acylated Lys26 are photodegradable, 1-2 hour direct sun exposure can reduce activity by 5-15%. - Vigorous agitation: semaglutide forms reversible oligomers in solution (dimers and trimers via C18), mechanical agitation can favour irreversible insoluble aggregates. - Mixing with other peptides in same vial: unpredictable interactions with pH / ionic strength / other lipophilic residues. One vial = one peptide. Recommended reconstitution with bacteriostatic water 0.9% benzyl alcohol. Typical reconstitution volume depending on nominal dosage (detailed below in Protocols section). Reconstituted peptide presents a clear solution, possibly slightly opalescent after a few hours (reversible C18 micro-oligomer formation), colourless. Any yellow or brown colouration signals oxidation or contamination -> rejection. Alteration visual indicators: solution that remains turbid, appearance of floating particles, formation of deposit at vial bottom, perceptible odour (normally odourless), swollen vial (possible suspect internal pressure). Faced with any of these signs, discard the vial and use a new one.

Mechanism of action

Semaglutide is a complete and selective GLP-1 receptor agonist (Glucagon-Like Peptide-1 Receptor, GLP-1R), resulting from sophisticated molecular engineering carried out by Novo Nordisk on the native scaffold of endogenous human GLP-1. The base peptide is modified at three critical positions to simultaneously resolve the two major limitations of native GLP-1: plasma half-life of 1-2 minutes (rapid degradation by dipeptidyl peptidase-4, DPP-4) and weak albumin affinity compromising duration of action.

Semaglutide structural modifications (described by Lau et al 2015, J Med Chem):

Ala8 to Aib (alpha-aminoisobutyrate) substitution: totally blocks DPP-4 cleavage at the N-terminal site, primary cause of native GLP-1 inactivation.
Lys34 to Arg34 substitution: removes a potential glycation site and stabilises conformation.
Lys26 acylation with C18 diacid fatty chain (octadecanedioic acid) via glutamic linker: creates a highly lipophilic covalent anchor that reversibly binds to serum albumin.

Semaglutide's GLP-1R selectivity distinguishes it from dual agonists (Tirzepatide GLP-1/GIP) or triple agonists (Retatrutide GLP-1/GIP/GCGR). This monospecificity offers a more predictable and better-characterised pharmacological profile (extensive clinical corpus SUSTAIN + STEP + SELECT), but limits metabolic amplitude vs more recent multi-receptor agonists. Semaglutide nevertheless remains the historical reference of the class and the best-documented GLP-1 molecule to date.

Frequently asked questions

How is semaglutide stored?

Unopened lyophilised vial: 24 months at 15-25°C protected from light, original cardboard packaging. After reconstitution: 21-28 days at strict 2-8°C (refrigerator), vertical position, protect from light. Never freeze (freeze-thaw cycles denature the peptide, 20-40% activity loss per cycle). Visually inspect before each use: solution should be clear or slightly opalescent (normal reversible C18 micro-oligomer formation), without yellow or brown colouration. Any lasting turbidity, particle, deposit or colouration = vial rejection.

Full guide: Semaglutide — mechanism and studies